Summer Research Projects at Frederick National Laboratory for Cancer Research
Thank you for your interest in this opportunity. We have received a large number of interested students and we are working with Frederick Lab to consider the applicants. The application process is now closed. There will be opportunities in the future and we will reach out to program directors when they become available.
Frederick National Laboratory for Cancer Research has several summer internship opportunities available within molecular biology, cancer cell biology, molecular imaging, biological assay development, and computational modeling/programming. The internship dates are flexible based on the student’s availability and the needs of the mentor and would usually last 10 weeks.
Students in the following disciplines are encouraged to apply: Biochemistry and Molecular Biology, Cell Biology, Tumor Biology, Data Analytics, Math/Stats, Computer Science, and Pharmacology
These opportunities are open to undergraduate rising seniors, master’s and PhD students. Projects can be tailored to the level of student.
Funds for stipends may be available through Georgetown University.
Below are opportunity areas. If you are interested, please complete this expression of interest.
All opportunities, except #4, are located at: Advanced Technology Research Facility, 8560 Progress Drive, Frederick, MD 21777
1. Develop and utilize drug screening platform to support KRAS inhibitor drug discovery.
Specific tasks would be: 1) screen a panel of isogenic cell lines expressing a single isoform of RAS for expression of broader RAS family proteins in development of a drug screening platform; 2) use this drug screening platform in a panel of high throughput assays as a tool for developing KRAS inhibitors.
2. Perform computational modeling of RAS protein, including molecular docking calculations, molecular visualization and molecular dynamics.
The students would: 1) perform molecular docking calculations to RAS through which they will aid in discovering molecules that bind to RAS and learn about molecular forces that govern binding and 2) perform structural analysis of KRAS, NRAS and HRAS through molecular visualization and molecular dynamics. Student would gain technical skills such as computer programing and navigating the UNIX/Linux operating system.
3. Investigate biological activities of RAS protein.
Support biological studies on RAS protein, including cell studies, Western blots and imaging. Another project focuses on assay development to investigate RAS signaling, including learning protein-protein interaction assays.
4. Computational biology to accelerate cancer research.
Specific tasks include: translate computational models for broader use and build a ‘clearing house’ for computational models. Support efforts for the Joint Design of Advanced Computing Solutions for Cancer (JDACS4C; https://datascience.cancer.gov/collaborations/joint-design-advanced-computing). Note: This opportunity is located at 9609 Medical Center Dr., Rockville, MD 20850.
5. Electron Microscopy: a very powerful technique to understand biological systems.
The research goals for the student will be to be able to understand the entire electron microscopy pipeline, from sample preparation to data collection and data analysis. The student will learn how to work with cells, viruses as well as protein-protein complexes.
6. Visualize anaphase catastrophe in lung cancer cells.
Anaphase catastrophe affects preferentially aneuploid cancer cells while sparing normal cells with two centrosomes. The detail mechanism of anaphase catastrophe is still under investigation. The project will focus on visualizing anaphase catastrophe by using fluorescence based live cell imaging technique.
We are no longer accepting applications as of April 4, 2019.